Upset Watch: Possible Week 12 Mid-Major and FCS Upsets

Oct 29, 2016; Houston, TX, USA; Houston Cougars defensive end Nick Thurman (91) celebrates after a defensive play during the fourth quarter against the Central Florida Knights at TDECU Stadium. The Cougars won 31-24. Mandatory Credit: Troy Taormina-USA TODAY Sports
Oct 29, 2016; Houston, TX, USA; Houston Cougars defensive end Nick Thurman (91) celebrates after a defensive play during the fourth quarter against the Central Florida Knights at TDECU Stadium. The Cougars won 31-24. Mandatory Credit: Troy Taormina-USA TODAY Sports /
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Oct 29, 2016; Houston, TX, USA; Houston Cougars defensive end Nick Thurman (91) celebrates after a defensive play during the fourth quarter against the Central Florida Knights at TDECU Stadium. The Cougars won 31-24. Mandatory Credit: Troy Taormina-USA TODAY Sports
Oct 29, 2016; Houston, TX, USA; Houston Cougars defensive end Nick Thurman (91) celebrates after a defensive play during the fourth quarter against the Central Florida Knights at TDECU Stadium. The Cougars won 31-24. Mandatory Credit: Troy Taormina-USA TODAY Sports /

Louisville at Houston (Thursday/8:00 pm)

Week 12’s upset opportunities kick off with a bang on Thursday night when Louisville visits Houston. Just a few weeks ago, this looked like a potential clash between teams battling to make the College Football Playoff field. While the Cardinals still have a shot to play in the ACC title game and could even make the semifinals without winning their conference, Houston has fallen back to earth after a season-opening win over Big 12 frontrunner Oklahoma and a 5-0 start.

The hosts are dealing with lingering injuries to both starting quarterback Greg Ward Jr. and his backup Kyle Postma, but they have a defense ranked third nationally in rushing yards allowed and ninth in total yardage given up to opponents. They rank in the top 20 in opponent third-down conversion rate and tied for 10th in fourth-down allowance. Louisville counters with dynamic Heisman frontrunner Lamar Jackson, and something will have to give in Texas on Thursday night.