ACC Football: 5 teams on upset alert in Week 3

Just one week after knocking off the Auburn Tigers at home, Clemson has to travel to Louisville to face another top 15 opponent. Junior quarterback Kelly Bryant showed out in the second half against Auburn and will be challenged once again.

The reigning Heisman Trophy winner Lamar Jackson is looking every bit the part in 2017. He went over 500 total yards last week against UNC. However, the Clemson defensive line was dominant against Auburn.

Quarterback Jarrett Stidham was never able to get away from the Clemson pass rush as they brought him down 11 times. Jackson is much more mobile than Stidham but still is facing one of the best, if not the best, defensive line in the country.

Next: 5 overreactions form Auburn's loss to Clemson

Clemson is a 3.5-point favorite. Last year, they defeated Jackson and the Cardinals at home in the final seconds of the fourth quarter on a failed fourth down attempt. This will be the most entertaining matchup of the weekend, especially if Louisville wins.