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College Football Predictions: Picks for Top games of Week 5

By Chris Peterson

Sep 9, 2023; Waco, Texas, USA; Utah Utes head coach Kyle Whittingham on the sidelines during the first half against the Baylor Bears at McLane Stadium. Mandatory Credit: Raymond Carlin III-USA TODAY Sports
Sep 9, 2023; Waco, Texas, USA; Utah Utes head coach Kyle Whittingham on the sidelines during the first half against the Baylor Bears at McLane Stadium. Mandatory Credit: Raymond Carlin III-USA TODAY Sports /
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Sep 23, 2023; Tempe, Arizona, USA; USC Trojans quarterback Caleb Williams (13) leaves the field after a 42-28 victory over the Arizona State Sun Devils at Mountain America Stadium. Mandatory Credit: Rob Schumacher-Arizona Republic
Sep 23, 2023; Tempe, Arizona, USA; USC Trojans quarterback Caleb Williams (13) leaves the field after a 42-28 victory over the Arizona State Sun Devils at Mountain America Stadium. Mandatory Credit: Rob Schumacher-Arizona Republic /

No. 8 USC (-21.5) at Colorado (Saturday 12 PM EST, Fox Sports)

This one could get ugly like it did last week for Colorado football against Oregon. The Ducks have an explosive offense and a stellar defense.

While we know that USC has Caleb Williams, who tops our quarterback power rankings once again, the defense is still a bit of a question mark. It hasn’t been challenged all that much and the game against Arizona State was admittedly closer than expected.

Still, the game features two of the top pass offenses in college football, plus Shedeur Sanders. It’s not expected that Travis Hunter will play, as badly as he wants to, and his presence will be missed on both sides of the field.

Williams has to be licking his chops facing the 129th-best defense in terms of yards allowed in college football. Things will be more competitive for Colorado last week, but the Ducks exposed the Buffs.

USC 45, Colorado 20

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