The oddsmakers continue to disrespect Indiana with opening line against Oregon

Oct 11, 2025; Eugene, Oregon, USA; Oregon Ducks head coach Dan Lanning shakes hands with Indiana Hoosiers head coach Curt Cignetti after Indiana defeated Oregon by the score of 30-20 at Autzen Stadium. Mandatory Credit: Troy Wayrynen-Imagn Images
Oct 11, 2025; Eugene, Oregon, USA; Oregon Ducks head coach Dan Lanning shakes hands with Indiana Hoosiers head coach Curt Cignetti after Indiana defeated Oregon by the score of 30-20 at Autzen Stadium. Mandatory Credit: Troy Wayrynen-Imagn Images | Troy Wayrynen-Imagn Images

This College Football Playoff, we're seeing several rematches of regular-season games with Alabama Vs Oklahoma, Tulane Vs Ole Miss, and Georgia Vs Ole Miss. After Indiana demolished Alabama and Oregon knocked off Texas Tech, we'll see one more rematch as Indiana and Oregon face off in the College Football Playoff semifinals.

The first matchup was played in Eugene, and it didn't matter as Curt Cignetti's team won the game 30-20. After Oregon tied the game on a pick 6 by Brandon Finney Jr, the game was all Indiana as the Hoosiers went on a 10-0 run to close the game.

The initial line for Oregon Vs Indiana suggests a much closer game

After Indiana capped off its win against Alabama, the oddsmakers went to work setting the line for the latest rematch in the College Football Playoff. According to FanDuel Sportsbook, the Indiana Hoosiers open as 4.5-point favorites over the Ducks while the total is set at 47.5 points.

All odds and lines are subject to change

The line opening at just 4.5 points indicates that the oddsmakers feel this rematch is going to be a much closer game than we saw in the first matchup. While Indiana won by 10 points, the second half felt dominated by Indiana as a rare mistake by Fernando Mendoza allowed the Ducks some false hope.

The Oregon Ducks have gotten much healthier as the College Football Playoff started, and they've looked like a complete team. The Ducks have picked up two Playoff wins by blowing out James Madison, while they just sent a statement shutting out Texas Tech as the defense came to play.

Curt Cignetti and Dan Lanning have become the top coaches in the Big Ten and Dante Moore will be trying to push Fernando Mendoza to be the first quarterback off the board making this rematch such a great game.

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